The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic.
Identifieur interne : 000039 ( Main/Exploration ); précédent : 000038; suivant : 000040The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic.
Auteurs : Ramiro Ortiz Moyano [Argentine] ; Fernanda Raya Tonetti [Argentine] ; Mikado Tomokiyo [Japon] ; Paulraj Kanmani [Corée du Sud] ; María Guadalupe Vizoso-Pinto [Argentine] ; Hojun Kim [Corée du Sud] ; Sandra Quilodrán-Vega [Chili] ; Vyacheslav Melnikov [Russie] ; Susana Alvarez [Argentine] ; Hideki Takahashi [Japon] ; Shoichiro Kurata [Japon] ; Haruki Kitazawa [Japon] ; Julio Villena [Argentine, Japon]Source :
- Microorganisms [ 2076-2607 ] ; 2020.
Abstract
We investigated whether the ability of commensal respiratory bacteria to modulate the innate immune response against bacterial and viral pathogens was a shared or strain-specific characteristic. Bacterial strains belonging to the Corynebacterium pseudodiphtheriticum and Dolosigranulum pigrum species were compared by studying their influence in the Toll-like receptor (TLR)-2- and TLR3-triggered immune responses in the respiratory tract, as well as in the resistance to Respiratory Syncytial Virus (RSV) and Streptococcus pneumoniae infections. We demonstrated that nasally administered C. pseudodiphteriticum 090104 or D. pigrum 040417 were able to modulate respiratory immunity and increase the resistance against pathogens, while other strains of the same species did not influence the respiratory immune responses, demonstrating a clear strain-dependent immunomodulatory effect of respiratory commensal bacteria. We also reported here that bacterium-like particles (BLP) and cell walls derived from immunomodulatory respiratory commensal bacteria are an interesting alternative for the modulation of the respiratory immune system. Our study is a step forward in the positioning of certain strains of respiratory commensal bacteria as next-generation probiotics for the respiratory tract.
DOI: 10.3390/microorganisms8050727
PubMed: 32414154
PubMed Central: PMC7285514
Affiliations:
- Argentine, Chili, Corée du Sud, Japon, Russie
- District fédéral central, Région de Tōhoku
- Moscou, Sendai
- Université du Tōhoku
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Genética, Facultad de Medicina, Universidad Nacional de Tucumán, 4000 Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratorio de Ciencias Básicas & Or. 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Genética, Facultad de Medicina, Universidad Nacional de Tucumán, 4000 Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratorio de Ciencias Básicas & Or. Genética, Facultad de Medicina, Universidad Nacional de Tucumán, 4000 Tucumán</wicri:regionArea><wicri:noRegion>4000 Tucumán</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Hojun" sort="Kim, Hojun" uniqKey="Kim H" first="Hojun" last="Kim">Hojun Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Korean Medicine, Dongguk University, Goyang 410-050, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Korean Medicine, Dongguk University, Goyang 410-050</wicri:regionArea><wicri:noRegion>Goyang 410-050</wicri:noRegion></affiliation></author><author><name sortKey="Quilodran Vega, Sandra" sort="Quilodran Vega, Sandra" uniqKey="Quilodran Vega S" first="Sandra" last="Quilodrán-Vega">Sandra Quilodrán-Vega</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Food Microbiology, Faculty of Veterinary Sciences, University of Concepción, 3780000 Chillán, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Laboratory of Food Microbiology, Faculty of Veterinary Sciences, University of Concepción, 3780000 Chillán</wicri:regionArea><wicri:noRegion>3780000 Chillán</wicri:noRegion></affiliation></author><author><name sortKey="Melnikov, Vyacheslav" sort="Melnikov, Vyacheslav" uniqKey="Melnikov V" first="Vyacheslav" last="Melnikov">Vyacheslav Melnikov</name><affiliation wicri:level="1"><nlm:affiliation>Gabrichevsky Research Institute for Epidemiology and Microbiology, 125212 Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Gabrichevsky Research Institute for Epidemiology and Microbiology, 125212 Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Alvarez, Susana" sort="Alvarez, Susana" uniqKey="Alvarez S" first="Susana" last="Alvarez">Susana Alvarez</name><affiliation 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type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Plant Immunology Unit, International Education and Research Center for Food and Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Plant Immunology Unit, International Education and Research Center for Food and Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author><author><name sortKey="Kurata, Shoichiro" sort="Kurata, Shoichiro" uniqKey="Kurata S" first="Shoichiro" last="Kurata">Shoichiro Kurata</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Molecular Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 981-8555, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Molecular Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 981-8555</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author><author><name sortKey="Kitazawa, Haruki" sort="Kitazawa, Haruki" uniqKey="Kitazawa H" first="Haruki" last="Kitazawa">Haruki Kitazawa</name><affiliation wicri:level="4"><nlm:affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Livestock Immunology Unit, International Education and Research Center for Food and Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Livestock Immunology Unit, International Education and Research Center for Food and Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author><author><name sortKey="Villena, Julio" sort="Villena, Julio" uniqKey="Villena J" first="Julio" last="Villena">Julio Villena</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), 4000 Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), 4000 Tucumán</wicri:regionArea><wicri:noRegion>4000 Tucumán</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32414154</idno><idno type="pmid">32414154</idno><idno type="doi">10.3390/microorganisms8050727</idno><idno type="pmc">PMC7285514</idno><idno type="wicri:Area/Main/Corpus">000130</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000130</idno><idno type="wicri:Area/Main/Curation">000130</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000130</idno><idno type="wicri:Area/Main/Exploration">000130</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic.</title><author><name sortKey="Ortiz Moyano, Ramiro" sort="Ortiz Moyano, Ramiro" uniqKey="Ortiz Moyano R" first="Ramiro" last="Ortiz Moyano">Ramiro Ortiz Moyano</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), 4000 Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), 4000 Tucumán</wicri:regionArea><wicri:noRegion>4000 Tucumán</wicri:noRegion></affiliation></author><author><name sortKey="Raya Tonetti, Fernanda" sort="Raya Tonetti, Fernanda" uniqKey="Raya Tonetti F" first="Fernanda" last="Raya Tonetti">Fernanda Raya Tonetti</name><affiliation wicri:level="1"><nlm:affiliation>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, 4000 Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, 4000 Tucumán</wicri:regionArea><wicri:noRegion>4000 Tucumán</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Ciencias Básicas & Or. Genética, Facultad de Medicina, Universidad Nacional de Tucumán, 4000 Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratorio de Ciencias Básicas & Or. Genética, Facultad de Medicina, Universidad Nacional de Tucumán, 4000 Tucumán</wicri:regionArea><wicri:noRegion>4000 Tucumán</wicri:noRegion></affiliation></author><author><name sortKey="Tomokiyo, Mikado" sort="Tomokiyo, Mikado" uniqKey="Tomokiyo M" first="Mikado" last="Tomokiyo">Mikado Tomokiyo</name><affiliation wicri:level="4"><nlm:affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Livestock Immunology Unit, International Education and Research Center for Food and Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Livestock Immunology Unit, International Education and Research Center for Food and Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author><author><name sortKey="Kanmani, Paulraj" sort="Kanmani, Paulraj" uniqKey="Kanmani P" first="Paulraj" last="Kanmani">Paulraj Kanmani</name><affiliation wicri:level="1"><nlm:affiliation>Department of Korean Medicine, Dongguk University, Goyang 410-050, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Korean Medicine, Dongguk University, Goyang 410-050</wicri:regionArea><wicri:noRegion>Goyang 410-050</wicri:noRegion></affiliation></author><author><name sortKey="Vizoso Pinto, Maria Guadalupe" sort="Vizoso Pinto, Maria Guadalupe" uniqKey="Vizoso Pinto M" first="María Guadalupe" last="Vizoso-Pinto">María Guadalupe Vizoso-Pinto</name><affiliation wicri:level="1"><nlm:affiliation>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, 4000 Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, 4000 Tucumán</wicri:regionArea><wicri:noRegion>4000 Tucumán</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Ciencias Básicas & Or. Genética, Facultad de Medicina, Universidad Nacional de Tucumán, 4000 Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratorio de Ciencias Básicas & Or. Genética, Facultad de Medicina, Universidad Nacional de Tucumán, 4000 Tucumán</wicri:regionArea><wicri:noRegion>4000 Tucumán</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Hojun" sort="Kim, Hojun" uniqKey="Kim H" first="Hojun" last="Kim">Hojun Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Korean Medicine, Dongguk University, Goyang 410-050, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Korean Medicine, Dongguk University, Goyang 410-050</wicri:regionArea><wicri:noRegion>Goyang 410-050</wicri:noRegion></affiliation></author><author><name sortKey="Quilodran Vega, Sandra" sort="Quilodran Vega, Sandra" uniqKey="Quilodran Vega S" first="Sandra" last="Quilodrán-Vega">Sandra Quilodrán-Vega</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Food Microbiology, Faculty of Veterinary Sciences, University of Concepción, 3780000 Chillán, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Laboratory of Food Microbiology, Faculty of Veterinary Sciences, University of Concepción, 3780000 Chillán</wicri:regionArea><wicri:noRegion>3780000 Chillán</wicri:noRegion></affiliation></author><author><name sortKey="Melnikov, Vyacheslav" sort="Melnikov, Vyacheslav" uniqKey="Melnikov V" first="Vyacheslav" last="Melnikov">Vyacheslav Melnikov</name><affiliation wicri:level="1"><nlm:affiliation>Gabrichevsky Research Institute for Epidemiology and Microbiology, 125212 Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Gabrichevsky Research Institute for Epidemiology and Microbiology, 125212 Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Alvarez, Susana" sort="Alvarez, Susana" uniqKey="Alvarez S" first="Susana" last="Alvarez">Susana Alvarez</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), 4000 Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), 4000 Tucumán</wicri:regionArea><wicri:noRegion>4000 Tucumán</wicri:noRegion></affiliation></author><author><name sortKey="Takahashi, Hideki" sort="Takahashi, Hideki" uniqKey="Takahashi H" first="Hideki" last="Takahashi">Hideki Takahashi</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Plant Pathology, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Plant Pathology, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Plant Immunology Unit, International Education and Research Center for Food and Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Plant Immunology Unit, International Education and Research Center for Food and Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author><author><name sortKey="Kurata, Shoichiro" sort="Kurata, Shoichiro" uniqKey="Kurata S" first="Shoichiro" last="Kurata">Shoichiro Kurata</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Molecular Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 981-8555, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Molecular Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 981-8555</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author><author><name sortKey="Kitazawa, Haruki" sort="Kitazawa, Haruki" uniqKey="Kitazawa H" first="Haruki" last="Kitazawa">Haruki Kitazawa</name><affiliation wicri:level="4"><nlm:affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Livestock Immunology Unit, International Education and Research Center for Food and Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Livestock Immunology Unit, International Education and Research Center for Food and Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author><author><name sortKey="Villena, Julio" sort="Villena, Julio" uniqKey="Villena J" first="Julio" last="Villena">Julio Villena</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), 4000 Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), 4000 Tucumán</wicri:regionArea><wicri:noRegion>4000 Tucumán</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author></analytic><series><title level="j">Microorganisms</title><idno type="ISSN">2076-2607</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated whether the ability of commensal respiratory bacteria to modulate the innate immune response against bacterial and viral pathogens was a shared or strain-specific characteristic. Bacterial strains belonging to the <i>Corynebacterium pseudodiphtheriticum</i> and <i>Dolosigranulum pigrum</i> species were compared by studying their influence in the Toll-like receptor (TLR)-2- and TLR3-triggered immune responses in the respiratory tract, as well as in the resistance to Respiratory Syncytial Virus (RSV) and <i>Streptococcus pneumoniae</i> infections. We demonstrated that nasally administered <i>C. pseudodiphteriticum</i> 090104 or <i>D. pigrum</i> 040417 were able to modulate respiratory immunity and increase the resistance against pathogens, while other strains of the same species did not influence the respiratory immune responses, demonstrating a clear strain-dependent immunomodulatory effect of respiratory commensal bacteria. We also reported here that bacterium-like particles (BLP) and cell walls derived from immunomodulatory respiratory commensal bacteria are an interesting alternative for the modulation of the respiratory immune system. Our study is a step forward in the positioning of certain strains of respiratory commensal bacteria as next-generation probiotics for the respiratory tract.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32414154</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">2076-2607</ISSN><JournalIssue CitedMedium="Print"><Volume>8</Volume><Issue>5</Issue><PubDate><Year>2020</Year><Month>May</Month><Day>13</Day></PubDate></JournalIssue><Title>Microorganisms</Title><ISOAbbreviation>Microorganisms</ISOAbbreviation></Journal><ArticleTitle>The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E727</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/microorganisms8050727</ELocationID><Abstract><AbstractText>We investigated whether the ability of commensal respiratory bacteria to modulate the innate immune response against bacterial and viral pathogens was a shared or strain-specific characteristic. Bacterial strains belonging to the <i>Corynebacterium pseudodiphtheriticum</i> and <i>Dolosigranulum pigrum</i> species were compared by studying their influence in the Toll-like receptor (TLR)-2- and TLR3-triggered immune responses in the respiratory tract, as well as in the resistance to Respiratory Syncytial Virus (RSV) and <i>Streptococcus pneumoniae</i> infections. We demonstrated that nasally administered <i>C. pseudodiphteriticum</i> 090104 or <i>D. pigrum</i> 040417 were able to modulate respiratory immunity and increase the resistance against pathogens, while other strains of the same species did not influence the respiratory immune responses, demonstrating a clear strain-dependent immunomodulatory effect of respiratory commensal bacteria. We also reported here that bacterium-like particles (BLP) and cell walls derived from immunomodulatory respiratory commensal bacteria are an interesting alternative for the modulation of the respiratory immune system. Our study is a step forward in the positioning of certain strains of respiratory commensal bacteria as next-generation probiotics for the respiratory tract.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ortiz Moyano</LastName><ForeName>Ramiro</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), 4000 Tucumán, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raya Tonetti</LastName><ForeName>Fernanda</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, 4000 Tucumán, Argentina.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratorio de Ciencias Básicas & Or. Genética, Facultad de Medicina, Universidad Nacional de Tucumán, 4000 Tucumán, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tomokiyo</LastName><ForeName>Mikado</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Livestock Immunology Unit, International Education and Research Center for Food and Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kanmani</LastName><ForeName>Paulraj</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Korean Medicine, Dongguk University, Goyang 410-050, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vizoso-Pinto</LastName><ForeName>María Guadalupe</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, 4000 Tucumán, Argentina.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratorio de Ciencias Básicas & Or. Genética, Facultad de Medicina, Universidad Nacional de Tucumán, 4000 Tucumán, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Hojun</ForeName><Initials>H</Initials><Identifier Source="ORCID">0000-0003-1038-0142</Identifier><AffiliationInfo><Affiliation>Department of Korean Medicine, Dongguk University, Goyang 410-050, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quilodrán-Vega</LastName><ForeName>Sandra</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Laboratory of Food Microbiology, Faculty of Veterinary Sciences, University of Concepción, 3780000 Chillán, Chile.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Melnikov</LastName><ForeName>Vyacheslav</ForeName><Initials>V</Initials><Identifier Source="ORCID">0000-0002-0825-7930</Identifier><AffiliationInfo><Affiliation>Gabrichevsky Research Institute for Epidemiology and Microbiology, 125212 Moscow, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alvarez</LastName><ForeName>Susana</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0002-9683-0337</Identifier><AffiliationInfo><Affiliation>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), 4000 Tucumán, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Takahashi</LastName><ForeName>Hideki</ForeName><Initials>H</Initials><Identifier Source="ORCID">0000-0001-5398-1867</Identifier><AffiliationInfo><Affiliation>Laboratory of Plant Pathology, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Plant Immunology Unit, International Education and Research Center for Food and Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kurata</LastName><ForeName>Shoichiro</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0002-0301-872X</Identifier><AffiliationInfo><Affiliation>Laboratory of Molecular Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 981-8555, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kitazawa</LastName><ForeName>Haruki</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Livestock Immunology Unit, International Education and Research Center for Food and Agricultural Immunology (CFAI), Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Villena</LastName><ForeName>Julio</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0003-4941-4960</Identifier><AffiliationInfo><Affiliation>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), 4000 Tucumán, Argentina.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>16H06429, 16K21723, and 16H06435</GrantID><Agency>Ministry of Education, Culture, Science, Sports, and Technology (MEXT) of Japan</Agency><Country></Country></Grant><Grant><GrantID>No. 01002A</GrantID><Agency>ARO Bio-oriented Technology Research Advancement Institution</Agency><Country></Country></Grant><Grant><GrantID>(FRiD)</GrantID><Agency>ohoku University Research Program "Frontier Research in Duo"</Agency><Country></Country></Grant><Grant><GrantID>PICT-2016-0410</GrantID><Agency>Agencia Nacional de Promoción Científica y Tecnológica</Agency><Country></Country></Grant><Grant><GrantID>19H00965</GrantID><Agency>Japan Society for the Promotion of Science</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Microorganisms</MedlineTA><NlmUniqueID>101625893</NlmUniqueID><ISSNLinking>2076-2607</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Corynebacterium pseudodiphtheriticum</Keyword><Keyword MajorTopicYN="N">Dolosigranulum pigrum</Keyword><Keyword MajorTopicYN="N">Streptococcus pneumoniae</Keyword><Keyword MajorTopicYN="N">TLR2</Keyword><Keyword 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Villena</name></country><country name="Corée du Sud"><noRegion><name sortKey="Kanmani, Paulraj" sort="Kanmani, Paulraj" uniqKey="Kanmani P" first="Paulraj" last="Kanmani">Paulraj Kanmani</name></noRegion><name sortKey="Kim, Hojun" sort="Kim, Hojun" uniqKey="Kim H" first="Hojun" last="Kim">Hojun Kim</name></country><country name="Chili"><noRegion><name sortKey="Quilodran Vega, Sandra" sort="Quilodran Vega, Sandra" uniqKey="Quilodran Vega S" first="Sandra" last="Quilodrán-Vega">Sandra Quilodrán-Vega</name></noRegion></country><country name="Russie"><region name="District fédéral central"><name sortKey="Melnikov, Vyacheslav" sort="Melnikov, Vyacheslav" uniqKey="Melnikov V" first="Vyacheslav" last="Melnikov">Vyacheslav Melnikov</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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